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Crucial Role for Prion Protein Membrane Anchoring in the Neuroinvasion and Neural Spread of Prion Infection

In nature prion diseases are usually transmitted by extracerebral prion infection, but clinical disease results only after invasion of the central nervous system (CNS). Prion protein (PrP), a host-encoded glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein, is necessary for prion infec...

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Detaylı Bibliyografya
Asıl Yazarlar: Klingeborn, Mikael, Race, Brent, Meade-White, Kimberly D., Rosenke, Rebecca, Striebel, James F., Chesebro, Bruce
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028874/
https://ncbi.nlm.nih.gov/pubmed/21123371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02167-10
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