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Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions

Prions are unconventional infectious agents that cause transmissible spongiform encephalopathy (TSE) diseases, or prion diseases. The biochemical nature of the prion infectious agent remains unclear. Previously, using a protein misfolding cyclic amplification (PMCA) reaction, infectivity and disease...

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Detalhes bibliográficos
Main Authors: Klingeborn, Mikael, Race, Brent, Meade-White, Kimberly D., Chesebro, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228482/
https://ncbi.nlm.nih.gov/pubmed/22065744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111255108
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