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Validating cancer drug targets through chemical genetics

Targeted therapies for cancer promise to revolutionize treatment by specifically inactivating pathways needed for the growth of tumor cells. The most prominent example of such therapy is imatinib (Gleevec), which targets the Bcr-Abl kinase and provides an effective low-toxicity treatment for chronic...

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Hlavní autoři: Burkard, Mark E., Jallepalli, Prasad V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028588/
https://ncbi.nlm.nih.gov/pubmed/20708654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbcan.2010.08.002
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