Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice

OBJECTIVE: Induction of mixed or complete chimerism via hematopoietic cell transplantation (HCT) from nonautoimmune donors could prevent or reverse type 1 diabetes (T1D). In clinical settings, HLA-matched HCT is preferred to facilitate engraftment and reduce the risk for graft versus host disease (G...

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Hlavní autoři: Racine, Jeremy, Wang, Miao, Zhang, Chunyan, Lin, Chia-Lei, Liu, Hongjun, Todorov, Ivan, Atkinson, Mark, Zeng, Defu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028355/
https://ncbi.nlm.nih.gov/pubmed/21270266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0827
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