A ceramide analog inhibits cPLA(2) activity and consequent PGE(2) formation in LPS-stimulated macrophages

Prostaglandin E(2) (PGE(2)) is an important mediator of the inflammatory response. Phospho-ceramide analogue-1 (PCERA-1), a synthetic phospholipid-like molecule, was previously reported to modulate pro- and anti-inflammatory cytokine production. We show here that PCERA-1 inhibited LPS-stimulated PGE...

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Autori principali: Goldsmith, Meir, Daka, Ala, Lamour, Nadia F., Mashiach, Roi, Glucksam, Yifat, Meijler, Michael M., Chalfant, Charles E., Zor, Tsaffrir
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026855/
https://ncbi.nlm.nih.gov/pubmed/21040745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2010.10.014
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