(S)-Tetrahydroisoquinoline Alkaloid Inhibits LPS-Induced Arachidonic Acid Release through Downregulation of cPLA(2) Expression

Sepsis, a systemic inflammatory response syndrome, remains a potentially lethal condition. (S)-1-α-Naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) is noted as a drug candidate for sepsis. Many studies have demonstrated its significant anti-inflammatory effects. Here we first exa...

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Main Authors: Choi, Jong Min, Choi, Young Hwa, Kim, Seok Kyun, Ahn, Kyong Hoon, Won, Jong Hoon, Lim, Joo Hyuk, Jang, You Jin, Lee, Sungsook, Kim, Dal-Hyun, Kim, Dae Kyong
Formato: Artigo
Idioma:Inglês
Publicado em: Korea Society for Molecular and Cellular Biology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887938/
https://ncbi.nlm.nih.gov/pubmed/24293010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-013-0078-x
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