Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by cytoplasmic protein aggregates in the brain and spinal cord that include TAR-DNA binding protein 43 (TDP-43). TDP-43 is normally localized in the nucleus with roles in the regulation of gene express...

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Détails bibliographiques
Auteurs principaux: Igaz, Lionel M., Kwong, Linda K., Lee, Edward B., Chen-Plotkin, Alice, Swanson, Eric, Unger, Travis, Malunda, Joe, Xu, Yan, Winton, Matthew J., Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026736/
https://ncbi.nlm.nih.gov/pubmed/21206091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44867
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