Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by cytoplasmic protein aggregates in the brain and spinal cord that include TAR-DNA binding protein 43 (TDP-43). TDP-43 is normally localized in the nucleus with roles in the regulation of gene express...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Igaz, Lionel M., Kwong, Linda K., Lee, Edward B., Chen-Plotkin, Alice, Swanson, Eric, Unger, Travis, Malunda, Joe, Xu, Yan, Winton, Matthew J., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026736/
https://ncbi.nlm.nih.gov/pubmed/21206091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44867
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados