Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

TAR DNA-binding protein 43 (TDP-43) is the disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). Although normal TDP-43 is a nuclear protein, pathological TDP-43 is redistributed and sequestered as insoluble aggregat...

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Detalhes bibliográficos
Main Authors: Winton, Matthew J., Igaz, Lionel M., Wong, Margaret M., Kwong, Linda K., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442318/
https://ncbi.nlm.nih.gov/pubmed/18305110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800342200
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