Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

The disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS) was identified recently as the TDP-43 (TAR DNA-binding protein 43), thereby providing a molecular link between these two disorders. In FTLD-U and ALS, TDP-43 i...

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Détails bibliographiques
Auteurs principaux: Igaz, Lionel M., Kwong, Linda K., Chen-Plotkin, Alice, Winton, Matthew J., Unger, Travis L., Xu, Yan, Neumann, Manuela, Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Molecular Basis of Cell and Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659210/
https://ncbi.nlm.nih.gov/pubmed/19164285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809462200
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