Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice

Ventricular preexcitation, a feature of Wolff-Parkinson-White syndrome, is caused by accessory myocardial pathways that bypass the annulus fibrosus. This condition increases the risk of atrioventricular tachycardia and, in the presence of atrial fibrillation, sudden death. The developmental mechanis...

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Main Authors: Aanhaanen, Wim T.J., Boukens, Bastiaan J.D., Sizarov, Aleksander, Wakker, Vincent, de Gier-de Vries, Corrie, van Ginneken, Antoni C., Moorman, Antoon F.M., Coronel, Ruben, Christoffels, Vincent M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026729/
https://ncbi.nlm.nih.gov/pubmed/21266775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44350
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