Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

Genome-wide association studies have implicated common genomic variants in the gene desert upstream of TBX3 in cardiac conduction velocity. Whether these noncoding variants affect expression of TBX3 or neighboring genes and how they affect cardiac conduction is not understood. Here, we use high-thro...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: van Weerd, Jan Hendrik, Mohan, Rajiv A, van Duijvenboden, Karel, Hooijkaas, Ingeborg B, Wakker, Vincent, Boukens, Bastiaan J, Barnett, Phil, Christoffels, Vincent M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365664/
https://ncbi.nlm.nih.gov/pubmed/32672536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56697
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