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Kinetic analysis in human brain of [(11)C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function
[(11)C](R)-rolipram provides a measure of the density of phosphodiesterase 4 (PDE4) in brain, an enzyme that metabolizes cAMP. The aims of this study were to perform kinetic modeling of [(11)C](R)-rolipram in healthy humans using an arterial input function and to replace this arterial input in human...
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Главные авторы: | , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
2010
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026385/ https://ncbi.nlm.nih.gov/pubmed/21034834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2010.10.064 |
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