Kinetic analysis in human brain of [(11)C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function

[(11)C](R)-rolipram provides a measure of the density of phosphodiesterase 4 (PDE4) in brain, an enzyme that metabolizes cAMP. The aims of this study were to perform kinetic modeling of [(11)C](R)-rolipram in healthy humans using an arterial input function and to replace this arterial input in human...

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Main Authors: Zanotti-Fregonara, Paolo, Zoghbi, Sami S., Liow, Jeih-San, Luong, Elise, Boellaard, Ronald, Gladding, Robert L., Pike, Victor W., Innis, Robert B., Fujita, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026385/
https://ncbi.nlm.nih.gov/pubmed/21034834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2010.10.064
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