Major histocompatibility complex class I molecules with super-enhanced CD8 binding properties bypass the requirement for cognate TCR recognition and non-specifically activate cytotoxic T lymphocytes1

CD8(+) cytotoxic T lymphocytes (CTL) are essential for effective immune defence against intracellular microbes and neoplasia. CTL recognize short peptide fragments presented in association with major histocompatibility complex class I (MHCI) molecules on the surface of infected or dysregulated cells...

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Detalhes bibliográficos
Main Authors: Wooldridge, Linda, Clement, Matthew, Lissina, Anna, Edwards, Emily S. J., Ladell, Kristin, Ekeruche, Julia, Hewitt, Rachel E., Laugel, Bruno, Gostick, Emma, Cole, David K., Debets, Reno, Berrevoets, Cor, Miles, John J., Burrows, Scott R., Price, David A., Sewell, Andrew K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024536/
https://ncbi.nlm.nih.gov/pubmed/20190139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902398
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