Anti-CD8 antibodies can trigger CD8(+) T-cell effector function in the absence of TCR engagement and improve pMHCI tetramer staining

CD8(+) T-cells recognize immunogenic peptides presented at the cell surface bound to major histocompatibility complex class I (MHCI) molecules. Antigen recognition involves the binding of both T-cell receptor (TCR) and CD8 co-receptor to the same peptide-MHCI (pMHCI) ligand. Specificity is determine...

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Detalhes bibliográficos
Main Authors: Clement, Mathew, Ladell, Kristin, Ekeruche-Makinde, Julia, Miles, John J., Edwards, Emily S. J., Dolton, Garry, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David K., Lauder, Sarah N., Gallimore, Awen M., Godkin, Andrew J., Burrows, Scott R., Price, David A., Sewell, Andrew K., Wooldridge, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145095/
https://ncbi.nlm.nih.gov/pubmed/21677135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003941
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