Anti-CD8 antibodies can trigger CD8(+) T-cell effector function in the absence of TCR engagement and improve pMHCI tetramer staining

CD8(+) T-cells recognize immunogenic peptides presented at the cell surface bound to major histocompatibility complex class I (MHCI) molecules. Antigen recognition involves the binding of both T-cell receptor (TCR) and CD8 co-receptor to the same peptide-MHCI (pMHCI) ligand. Specificity is determine...

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Hauptverfasser: Clement, Mathew, Ladell, Kristin, Ekeruche-Makinde, Julia, Miles, John J., Edwards, Emily S. J., Dolton, Garry, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David K., Lauder, Sarah N., Gallimore, Awen M., Godkin, Andrew J., Burrows, Scott R., Price, David A., Sewell, Andrew K., Wooldridge, Linda
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145095/
https://ncbi.nlm.nih.gov/pubmed/21677135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003941
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