Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population

The potential benefits of using population isolates in genetic mapping, such as reduced genetic, phenotypic and environmental heterogeneity, are offset by the challenges posed by the large amounts of direct and cryptic relatedness in these populations confounding basic assumptions of independence. W...

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Hlavní autoři: Kenny, Eimear E., Kim, Minseung, Gusev, Alexander, Lowe, Jennifer K., Salit, Jacqueline, Smith, J. Gustav, Kovvali, Sirisha, Kang, Hyun Min, Newton-Cheh, Christopher, Daly, Mark J., Stoffel, Markus, Altshuler, David M., Friedman, Jeffrey M., Eskin, Eleazar, Breslow, Jan L., Pe'er, Itsik
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Association Studies Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024042/
https://ncbi.nlm.nih.gov/pubmed/21118897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq510
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