Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population

The potential benefits of using population isolates in genetic mapping, such as reduced genetic, phenotypic and environmental heterogeneity, are offset by the challenges posed by the large amounts of direct and cryptic relatedness in these populations confounding basic assumptions of independence. W...

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Détails bibliographiques
Auteurs principaux: Kenny, Eimear E., Kim, Minseung, Gusev, Alexander, Lowe, Jennifer K., Salit, Jacqueline, Smith, J. Gustav, Kovvali, Sirisha, Kang, Hyun Min, Newton-Cheh, Christopher, Daly, Mark J., Stoffel, Markus, Altshuler, David M., Friedman, Jeffrey M., Eskin, Eleazar, Breslow, Jan L., Pe'er, Itsik
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
Sujets:
Association Studies Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024042/
https://ncbi.nlm.nih.gov/pubmed/21118897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq510
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