Whole population, genome-wide mapping of hidden relatedness

We present GERMLINE, a robust algorithm for identifying segmental sharing indicative of recent common ancestry between pairs of individuals. Unlike methods with comparable objectives, GERMLINE scales linearly with the number of samples, enabling analysis of whole-genome data in large cohorts. Our ap...

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Detalhes bibliográficos
Main Authors: Gusev, Alexander, Lowe, Jennifer K., Stoffel, Markus, Daly, Mark J., Altshuler, David, Breslow, Jan L., Friedman, Jeffrey M., Pe'er, Itsik
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652213/
https://ncbi.nlm.nih.gov/pubmed/18971310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.081398.108
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