Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population

The potential benefits of using population isolates in genetic mapping, such as reduced genetic, phenotypic and environmental heterogeneity, are offset by the challenges posed by the large amounts of direct and cryptic relatedness in these populations confounding basic assumptions of independence. W...

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Main Authors: Kenny, Eimear E., Kim, Minseung, Gusev, Alexander, Lowe, Jennifer K., Salit, Jacqueline, Smith, J. Gustav, Kovvali, Sirisha, Kang, Hyun Min, Newton-Cheh, Christopher, Daly, Mark J., Stoffel, Markus, Altshuler, David M., Friedman, Jeffrey M., Eskin, Eleazar, Breslow, Jan L., Pe'er, Itsik
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2011
נושאים:
Association Studies Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024042/
https://ncbi.nlm.nih.gov/pubmed/21118897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq510
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