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Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production
The copper chaperone for superoxide dismutase (CCS) binds to both the β-site AβPP cleaving enzyme (BACE1) and to the neuronal adaptor protein X11α. BACE1 initiates AβPP processing to produce the amyloid-β (Aβ) peptide deposited in the brains of Alzheimer’s disease patients. X11α also interacts direc...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023902/ https://ncbi.nlm.nih.gov/pubmed/20693630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100717 |
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