Instability of Superoxide Dismutase 1 of Drosophila in Mutants Deficient for Its Cognate Copper Chaperone

Copper,zinc superoxide dismutase (SOD1) in mammals is activated principally via a copper chaperone (CCS) and to a lesser degree by a CCS-independent pathway of unknown nature. In this study, we have characterized the requirement for CCS in activating SOD1 from Drosophila. A CCS-null mutant (Ccs(n)(2...

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Bibliografiske detaljer
Main Authors: Kirby, Kim, Jensen, Laran T., Binnington, Janet, Hilliker, Arthur J., Ulloa, Janella, Culotta, Valeria C., Phillips, John P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Enzyme Catalysis and Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602909/
https://ncbi.nlm.nih.gov/pubmed/18948262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807131200
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