Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production

The copper chaperone for superoxide dismutase (CCS) binds to both the β-site AβPP cleaving enzyme (BACE1) and to the neuronal adaptor protein X11α. BACE1 initiates AβPP processing to produce the amyloid-β (Aβ) peptide deposited in the brains of Alzheimer’s disease patients. X11α also interacts direc...

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Bibliographic Details
Main Authors: Gray, Emma H., De Vos, Kurt J., Dingwall, Colin, Perkinton, Michael S., Miller, Christopher C.J.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023902/
https://ncbi.nlm.nih.gov/pubmed/20693630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100717
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