DC expressing transgene Foxp3 are regulatory APC

Tolerogenic dendritic cells (DC) and suppressive Foxp3(+) Treg play important roles in preventing autoimmunity and allograft rejection. We report that (adenovirus-mediated) ectopic expression of Foxp3 in human DC (i.e. DC.Foxp3) yields an antigen presenting cell (APC) that severe limits T cell proli...

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Main Authors: Lipscomb, Michael W., Taylor, Jennifer L., Goldbach, Cristina J., Watkins, Simon C., Wesa, Amy K., Storkus, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023581/
https://ncbi.nlm.nih.gov/pubmed/19941313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939667
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