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INTRALESIONAL DELIVERY OF DENDRITIC CELLS ENGINEERED TO EXPRESS T-BET PROMOTES PROTECTIVE TYPE-1 IMMUNITY AND THE NORMALIZATION OF THE TUMOR MICROENVIRONMENT()
T-bet (Tbx21), a T-box transcription factor, has been previously identified as a master regulator of Type-1 T cell polarization. We have also recently shown that the genetic engineering of human DC to express hT-bet cDNA yields a Type-1 polarizing APC in vitro (1). In the current study, murine CD11c...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3151673/ https://ncbi.nlm.nih.gov/pubmed/20675595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001294 |
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