Ectopic T-bet expression licenses dendritic cells for interleukin (IL)-12-independent priming of Type-1 T cells in vitro

T-bet (TBX21) is a transcription factor required for the optimal development of Type-1 immune responses. While initially characterized for its intrinsic role in T cell functional polarization, endogenous T-bet may also be critical to the licensing of Type-1-biasing antigen presenting cells. Here, we...

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Detalhes bibliográficos
Main Authors: Lipscomb, Michael W., Chen, Lu, Taylor, Jennifer L., Goldbach, Christina, Watkins, Simon C., Kalinski, Pawel, Butterfield, Lisa H., Wesa, Amy K., Storkus, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921905/
https://ncbi.nlm.nih.gov/pubmed/19915058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901477
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