Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells

Murine dendritic cells (DC) transduced to express the Type-1 transactivator T-bet (i.e. mDC.Tbet) and delivered intratumorally (i.t.) as a therapy are superior to control wild-type DC in slowing the growth of established subcutaneous (s.c.) MCA205 sarcomas in vivo. Optimal anti-tumor efficacy of mDC...

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Detalhes bibliográficos
Main Authors: Chen, Lu, Taylor, Jennifer L., Sabins, Nina Chi, Lowe, Devin B., Qu, Yanyan, You, Zhaoyang, Storkus, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775601/
https://ncbi.nlm.nih.gov/pubmed/23846252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2013.42
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