Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal...

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Hlavní autoři: Ho, Michael, Hoke, David E., Chua, Yee Jia, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin, White, Anthony R., Evin, Geneviève
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE-Hindawi Access to Research 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021864/
https://ncbi.nlm.nih.gov/pubmed/21253550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/950932
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