Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ho, Michael, Hoke, David E., Chua, Yee Jia, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin, White, Anthony R., Evin, Geneviève
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021864/
https://ncbi.nlm.nih.gov/pubmed/21253550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/950932
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados