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Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal...

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Dettagli Bibliografici
Autori principali: Ho, Michael, Hoke, David E., Chua, Yee Jia, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin, White, Anthony R., Evin, Geneviève
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE-Hindawi Access to Research 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021864/
https://ncbi.nlm.nih.gov/pubmed/21253550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/950932
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