Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety

Knock-in mice were generated that harbored a leucine-to-serine mutation in the α4 nicotinic receptor near the gate in the channel pore. Mice with intact expression of this hypersensitive receptor display dominant neonatal lethality. These mice have a severe deficit of dopaminergic neurons in the sub...

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Detaylı Bibliyografya
Asıl Yazarlar: Labarca, Cesar, Schwarz, Johannes, Deshpande, Purnima, Schwarz, Sigrid, Nowak, Mark W., Fonck, Carlos, Nashmi, Raad, Kofuji, Paulo, Dang, Hong, Shi, Wenmei, Fidan, Melihat, Khakh, Baljit S., Chen, Zhoufeng, Bowers, Barbara J., Boulter, Jim, Wehner, Jeanne M., Lester, Henry A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC30217/
https://ncbi.nlm.nih.gov/pubmed/11226318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041582598
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