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Allosteric Control of Gating and Kinetics at P2X(4)Receptor Channels
The CNS abundantly expresses P2X receptor channels for ATP; of these the most widespread in the brain is the P2X(4)channel. We show that ivermectin (IVM) is a specific positive allosteric effector of heterologously expressed P2X(4) and possibly of heteromeric P2X(4)/P2X(6)channels, but not of P2X(2)...
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| Published in: | J Neurosci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Society for Neuroscience
1999
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6782529/ https://ncbi.nlm.nih.gov/pubmed/10460235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-17-07289.1999 |
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