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Allosteric Modulation of Ca(2+) flux in Ligand-gated Cation Channel (P2X4) by Actions on Lateral Portals
Human P2X receptors are a family of seven ATP-gated ion channels that transport Na(+), K(+), and Ca(2+) across cell surface membranes. The P2X4 receptor is unique among family members in its sensitivity to the macrocyclic lactone, ivermectin, which allosterically modulates both ion conduction and ch...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293559/ https://ncbi.nlm.nih.gov/pubmed/22219189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322461 |
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