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Allosteric Modulation of Ca(2+) flux in Ligand-gated Cation Channel (P2X4) by Actions on Lateral Portals

Human P2X receptors are a family of seven ATP-gated ion channels that transport Na(+), K(+), and Ca(2+) across cell surface membranes. The P2X4 receptor is unique among family members in its sensitivity to the macrocyclic lactone, ivermectin, which allosterically modulates both ion conduction and ch...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Samways, Damien S. K., Khakh, Baljit S., Egan, Terrance M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293559/
https://ncbi.nlm.nih.gov/pubmed/22219189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322461
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