Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety

Knock-in mice were generated that harbored a leucine-to-serine mutation in the α4 nicotinic receptor near the gate in the channel pore. Mice with intact expression of this hypersensitive receptor display dominant neonatal lethality. These mice have a severe deficit of dopaminergic neurons in the sub...

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Detalhes bibliográficos
Main Authors: Labarca, Cesar, Schwarz, Johannes, Deshpande, Purnima, Schwarz, Sigrid, Nowak, Mark W., Fonck, Carlos, Nashmi, Raad, Kofuji, Paulo, Dang, Hong, Shi, Wenmei, Fidan, Melihat, Khakh, Baljit S., Chen, Zhoufeng, Bowers, Barbara J., Boulter, Jim, Wehner, Jeanne M., Lester, Henry A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30217/
https://ncbi.nlm.nih.gov/pubmed/11226318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041582598
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