Increased Sensitivity to Agonist-Induced Seizures, Straub Tail, and Hippocampal Theta Rhythm in Knock-In Mice Carrying Hypersensitive α4 Nicotinic Receptors

We studied a strain of exon replacement mice (“L9′S knock-in”) whose α4 nicotinic receptor subunits have a leucine to serine mutation in the M2 region, 9′ position (Labarca et al., 2001); this mutation renders α4-containing receptors hypersensitive to agonists. Nicotine induced seizures at concentra...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Fonck, Carlos, Nashmi, Raad, Deshpande, Purnima, Damaj, M. Imad, Marks, Michael J., Riedel, Anett, Schwarz, Johannes, Collins, Allan C., Labarca, Cesar, Lester, Henry A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742094/
https://ncbi.nlm.nih.gov/pubmed/12684443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-07-02582.2003
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