Novel Seizure Phenotype and Sleep Disruptions in Knock-In Mice with Hypersensitive α4(*) Nicotinic Receptors

A leucine to alanine substitution (L9′A) was introduced in the M2 region of the mouse α4 neuronal nicotinic acetylcholine receptor (nAChR) subunit. Expressed in Xenopus oocytes, α4(L9′A)β2 nAChRs were ≥30-fold more sensitive than wild type (WT) to both ACh and nicotine. We generated knock-in mice wi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Fonck, Carlos, Cohen, Bruce N., Nashmi, Raad, Whiteaker, Paul, Wagenaar, Daniel A., Rodrigues-Pinguet, Nivalda, Deshpande, Purnima, McKinney, Sheri, Kwoh, Steven, Munoz, Jose, Labarca, Cesar, Collins, Allan C., Marks, Michael J., Lester, Henry A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2005
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725918/
https://ncbi.nlm.nih.gov/pubmed/16339034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3597-05.2005
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi