Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice

Duchenne muscular dystrophy (DMD) is caused by mutations in dystrophin and the subsequent disruption of the dystrophin-associated protein complex (DAPC). Utrophin is a dystrophin homolog expressed at high levels in developing muscle that is an attractive target for DMD therapy. Here we show that the...

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Библиографические подробности
Главные авторы: Amenta, Alison R., Yilmaz, Atilgan, Bogdanovich, Sasha, McKechnie, Beth A., Abedi, Mehrdad, Khurana, Tejvir S., Fallon, Justin R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021068/
https://ncbi.nlm.nih.gov/pubmed/21187385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013067108
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