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Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction
Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5646768/ https://ncbi.nlm.nih.gov/pubmed/29045431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182676 |
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