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Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction

Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mishra, Manoj K., Loro, Emanuele, Sengupta, Kasturi, Wilton, Steve D., Khurana, Tejvir S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646768/
https://ncbi.nlm.nih.gov/pubmed/29045431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182676
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