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High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy

Upregulation of endogenous utrophin offers great promise for treating DMD, as it can functionally compensate for the lack of dystrophin caused by DMD gene mutations, without the immunogenic concerns associated with delivering dystrophin. However, post-transcriptional repression mechanisms targeting...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Loro, Emanuele, Sengupta, Kasturi, Bogdanovich, Sasha, Whig, Kanupriya, Schultz, David C., Huryn, Donna M., Khurana, Tejvir S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005813/
https://ncbi.nlm.nih.gov/pubmed/32034254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58737-6
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