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High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy

Upregulation of endogenous utrophin offers great promise for treating DMD, as it can functionally compensate for the lack of dystrophin caused by DMD gene mutations, without the immunogenic concerns associated with delivering dystrophin. However, post-transcriptional repression mechanisms targeting...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Loro, Emanuele, Sengupta, Kasturi, Bogdanovich, Sasha, Whig, Kanupriya, Schultz, David C., Huryn, Donna M., Khurana, Tejvir S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005813/
https://ncbi.nlm.nih.gov/pubmed/32034254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58737-6
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