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High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy

Upregulation of endogenous utrophin offers great promise for treating DMD, as it can functionally compensate for the lack of dystrophin caused by DMD gene mutations, without the immunogenic concerns associated with delivering dystrophin. However, post-transcriptional repression mechanisms targeting...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Loro, Emanuele, Sengupta, Kasturi, Bogdanovich, Sasha, Whig, Kanupriya, Schultz, David C., Huryn, Donna M., Khurana, Tejvir S.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005813/
https://ncbi.nlm.nih.gov/pubmed/32034254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58737-6
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