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Subunit-specific degradation of the UmuD/D′ heterodimer by the ClpXP protease: the role of trans recognition in UmuD′ stability

The Escherichia coli UmuD′ protein is a subunit of the recently described error-prone DNA polymerase, pol V. UmuD′ is initially synthesized as an unstable and mutagenically inactive pro-protein, UmuD. Upon processing, UmuD′ assumes a relatively stable conformation and becomes mutagenically active. W...

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Detalhes bibliográficos
Main Authors: Gonzalez, Martín, Rasulova, Fatima, Maurizi, Michael R., Woodgate, Roger
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC302103/
https://ncbi.nlm.nih.gov/pubmed/11013227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.19.5251
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