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Alternating translocation of protein substrates from both ends of ClpXP protease

In ClpXP protease complexes, hexameric rings of the ATP-dependent ClpX chaperone stack on one or both faces of the double-heptameric rings of ClpP. We used electron microscopy to record the initial binding of protein substrates to ClpXP and their accumulation inside proteolytically inactive ClpP. Pr...

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Detalhes bibliográficos
Main Authors: Ortega, Joaquin, Lee, Hyun Sook, Maurizi, Michael R., Steven, Alasdair C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126282/
https://ncbi.nlm.nih.gov/pubmed/12234933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf483
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