Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

When ribosomes fail to complete normal translation, all cells have mechanisms to ensure degradation of the resulting partial proteins to safeguard proteome integrity. In Escherichia coli and other eubacteria, the tmRNA system rescues stalled ribosomes and adds an ssrA tag or degron to the C-terminus...

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Dades bibliogràfiques

Autors principals:	Xue Fei, Tristan A Bell, Sarah R Barkow, Tania A Baker, Robert T Sauer
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2020-10-01
Col·lecció:	eLife
Matèries:	AAA+ protease cryo-EM structures tmRNA tagging degradation specificity recognition complex intermediate complex
Accés en línia:	https://elifesciences.org/articles/61496
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