Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice
The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(–/–) background. CD45 suppresses th...
Kaydedildi:
| Yayımlandı: | EMBO J |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2000
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10970857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.17.4644 |
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