Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice

The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(–/–) background. CD45 suppresses th...

詳細記述

書誌詳細

出版年:	EMBO J
主要な著者:	Baker, Matthew, Gamble, John, Tooze, Reuben, Higgins, Dominic, Yang, Feng Tang, O’Brien, Patricia C.M., Coleman, Nicholas, Pingel, Sabine, Turner, Martin, Alexander, Denis R.
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2000
主題:	Articles
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10970857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.17.4644
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!