Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice

The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(–/–) background. CD45 suppresses th...

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Bibliographic Details
Main Authors: Baker, Matthew, Gamble, John, Tooze, Reuben, Higgins, Dominic, Yang, Feng Tang, O’Brien, Patricia C.M., Coleman, Nicholas, Pingel, Sabine, Turner, Martin, Alexander, Denis R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC302076/
https://ncbi.nlm.nih.gov/pubmed/10970857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4644
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