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Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice
The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(–/–) background. CD45 suppresses th...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2000
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302076/ https://ncbi.nlm.nih.gov/pubmed/10970857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4644 |
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