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Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice

The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(–/–) background. CD45 suppresses th...

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I publikationen:EMBO J
Huvudupphov: Baker, Matthew, Gamble, John, Tooze, Reuben, Higgins, Dominic, Yang, Feng Tang, O’Brien, Patricia C.M., Coleman, Nicholas, Pingel, Sabine, Turner, Martin, Alexander, Denis R.
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Publishing Group 2000
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC302076/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10970857/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.17.4644
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