Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

Hereditary hemochromatosis (HH) is a common disorder of iron metabolism caused by mutation in HFE, a gene encoding an MHC class I-like protein. Clinical studies demonstrate that the severity of iron loading is highly variable among individuals with identical HFE genotypes. To determine whether genet...

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Main Authors: Fleming, Robert E., Holden, Christopher C., Tomatsu, Shunji, Waheed, Abdul, Brunt, Elizabeth M., Britton, Robert S., Bacon, Bruce R., Roopenian, Derry C., Sly, William S.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2001
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC30203/
https://ncbi.nlm.nih.gov/pubmed/11226304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051630898
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