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Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

Hereditary hemochromatosis (HH) is a common disorder of iron metabolism caused by mutation in HFE, a gene encoding an MHC class I-like protein. Clinical studies demonstrate that the severity of iron loading is highly variable among individuals with identical HFE genotypes. To determine whether genet...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Fleming, Robert E., Holden, Christopher C., Tomatsu, Shunji, Waheed, Abdul, Brunt, Elizabeth M., Britton, Robert S., Bacon, Bruce R., Roopenian, Derry C., Sly, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30203/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226304/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051630898
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